Mounjaro vs Wegovy: Comparing Weight Loss Injections Mounjaro Vs Wegovy are both FDA-approved injectable medications designed for weight loss in adults with obesity or weight-related health conditions. Mounjaro targets both GIP and GLP-1 receptors, offering enhanced appetite control and improved insulin response. Wegovy targets only the GLP-1 receptor, effectively reducing hunger and calorie intake. Clinical studies suggest Mounjaro may lead to slightly greater weight loss than Wegovy. Both are administered weekly and require lifestyle changes like healthy eating and regular exercise. The choice between them depends on individual health profiles, side effects, and medical advice from a healthcare provider.